Klaus Fließbach

Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales

This paper introduces an automated method to quantify white matter hyperintensity confluence, showing it correlates with cognitive performance and dementia subtypes beyond volume.

Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer's Disease

The paper examines how disrupted forward connectivity in the parieto-temporal network relates to memory impairment and AD pathology using fMRI and DCM in a longitudinal study.

Dysfunction of the episodic memory network in the Alzheimer's disease cascade

This study examines how episodic memory network dysfunction relates to AD biomarkers, neurodegeneration, and cognition using longitudinal fMRI data from the DZNE study.

Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer's Disease Dementia using ELSI-Net

This paper introduces ELSI-Net, a deep learning method for automated Locus Coeruleus segmentation and feature extraction in aging and Alzheimer's Disease dementia, showing high agreement with manual ratings and correlations to CSF biomarkers.

Cognitive Reserve Against Alzheimer's Pathology Is Linked to Brain Activity During Memory Formation

The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

The paper examines if fractional anisotropy of the fornix mediates the link between Mediterranean diet adherence and verbal memory decline in older adults over four years.

Diagnostic images for mild cognitive impairment reveal biomarker status and abnormal scene processing

The paper identifies diagnostic images that correlate with Alzheimer's biomarkers and show differential neural processing in MCI patients compared to healthy controls.

Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

This study finds that lifelong musical activity is linked to better cognitive abilities and preserved brain structure in older adults, suggesting it may enhance cognitive resilience.

Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment

The paper assesses memorability of photographs in healthy controls, subjective cognitive decline, and mild cognitive impairment, identifying images with diagnostic potential.