Author

Nicola Jean Holden

Scotland's Rural CollegeORCID 0000-0002-7904-4529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ashley Ward· 1 shared Balaji VeeraraghavaniD· 1 shared Claudia E. CoipaniD· 1 shared David L. GallyiD· 1 shared Diego BarrialesiD· 1 shared Ed J Kuiper· 1 shared Eelco FranziD· 1 shared Els WesselsiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBioinformatics

Ashley Ward

Author profile →

3 papers

Recent·Most cited

Motile bacteria collectively transport soil water during host colonisation

Ilonka C. Engelhardt, Juan Anguíta, Diego Barriales, Tim J. Daniell, Nicola Jean Holden, Lionel Xavier Dupuy

This study tracks Bacillus subtilis movement in soil to show how bacteria modify fluid pathways to enhance collective transport during root colonisation.

bioRxiv · Sep 3, 2026 · PreprintMicrobiology

Stitching genomics data to protein structures: Virulence factors in non-O157 Shiga toxin-producing Escherichia coli

Sony Malhotra, Ashley Ward, Lauren Giles, Tom Gerrard, Martyn Winn, Nicola Jean Holden

The paper analyzes genetic variation in virulence factors of non-O157 STEC genomes and models their protein interactions to assess pathogenic potential.

bioRxiv · Jan 15, 2026 · PreprintBioinformatics

Genome Analyses of A Worldwide Multisource Collection of Klebsiella variicola Reveal Adaptation Relevant for Human Infection

Jiayu Wang, Claudia E. Coipan, Eelco Franz, Ed J Kuiper, Els Wessels, David L. Gally, Karthick Vasudevan, Balaji Veeraraghavan, Refath Farzana, Nicola Jean Holden, Ruth N. Zadoks, Paul G. Higgins, Thamarai Schneiders

This study analyzes the genome of Klebsiella variicola from diverse sources to identify genetic adaptations linked to human infection.

bioRxiv · Oct 28, 2024 · PreprintMicrobiology