NeurosciencebioRxiv
APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons
Vanessa Budny, Yannic Knöpfli, Deborah Meier…·Christian Tackenberg
This study shows APOE4 increases mitochondrial ATP production in neurons compared to other APOE isoforms, suggesting a gain-of-function effect on neuronal energy metabolism.
DOI 10.3390/cells13141207