Author

Vanessa Budny

University of Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Research Focus:differential expression· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christian TackenbergiD· 4 shared Chantal Bodenmann· 3 shared Ruslan RustiD· 3 shared Kathrin J. Zürcher· 2 shared R. WeberiD· 2 shared Sherida M. de LeeuwiD· 2 shared Anne‐Claude GaviniD· 1 shared Aron W.T. Kirschner· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Christian TackenbergORCID

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4 papers

Recent·Most cited

Hypoxia preconditioned neural xenografts promote repair of brain tissue after stroke

Nora H. Rentsch, R. Weber, Beatriz Achón Buil, Chantal Bodenmann, Kathrin J. Zürcher, Vanessa Budny, Melanie Generali, Christian Tackenberg, Ruslan Rust

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

bioRxiv · Sep 30, 2025 · PreprintNeuroscience

APOE genotype-dependent differences in human astrocytic energy metabolism

Vanessa Budny, Chantal Bodenmann, Kathrin J. Zürcher, Maik Krüger, Sherida M. de Leeuw, R. Weber, Ruslan Rust, Luca Ravotto, Iván Ruminot, L. Felipe Barros, Bruno Weber, Christian Tackenberg

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

Frontiers in Cellular Neuroscience · Sep 1, 2025Peer-reviewedNeuroscience

APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons

Vanessa Budny, Yannic Knöpfli, Deborah Meier, Kathrin Zürcher, Chantal Bodenmann, Siri L. Peter, Terry Müller, Marie Tardy, Cédric Cortijo, Christian Tackenberg

This study shows APOE4 increases mitochondrial ATP production in neurons compared to other APOE isoforms, suggesting a gain-of-function effect on neuronal energy metabolism.

bioRxiv · Jun 3, 2024Neuroscience

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytes

Sherida M. de Leeuw, Aron W.T. Kirschner, Karina Lindner, Ruslan Rust, Vanessa Budny, Witold Wolski, Anne‐Claude Gavin, Roger M. Nitsch, Christian Tackenberg

This study shows APOE alleles E2, E3, and E4 differentially affect astrocyte metabolism, cholesterol handling, and inflammation in isogenic iPSC-derived cells, with E4 showing disease-relevant dysregulation.

Stem Cell Reports · Jan 1, 2022Peer-reviewedNeuroscience