Christian Tackenberg

This study shows that using a dual safety switch to eliminate neural grafts after stroke impairs functional recovery despite effective cell ablation.

This paper develops CAR-NSC therapy targeting integrin αvβ3 to improve spatial distribution and tissue engagement of transplanted cells in stroke models.

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

This study creates a single-cell transcriptomic atlas of the mouse brain after stroke, revealing cell-specific molecular changes and shared features with human stroke lesions.

This study shows that delayed transplantation of neural progenitor cells after stroke improves graft survival and proliferation in mice.

This study shows APOE4 increases mitochondrial ATP production in neurons compared to other APOE isoforms, suggesting a gain-of-function effect on neuronal energy metabolism.

The paper introduces a semi-automated toolkit to estimate stroke infarct volumes in rodents using MRI and histological sections, showing high correlation between the two methods.

This paper develops a deep learning-based method for analyzing rodent stroke recovery using 3D gait tracking and benchmarking against conventional tests.

This paper develops xeno-free iPSC-derived NPCs compatible with GMP for clinical use, showing long-term survival and differentiation into neurons in vivo.

This study evaluates the impact of immunosuppression on stroke pathology in different mouse models, finding distinct anatomical and molecular changes that affect recovery and inflammation.

This study shows APOE alleles E2, E3, and E4 differentially affect astrocyte metabolism, cholesterol handling, and inflammation in isogenic iPSC-derived cells, with E4 showing disease-relevant dysregulation.