BioengineeringbioRxivPreprint
Megalin-mediated deterministic pseudotransduction in proximal tubules fundamentally challenges current understanding of AAV kidney transduction
Anusha Sairavi, Ranjan Das, Lena Li…·Hiroyuki Nakai
The paper shows that AAV-mediated gene delivery to proximal tubules is not direct but relies on megalin-mediated uptake of reporter proteins from other organs, challenging current understanding.
DOI 10.64898/2026.10.26.761697