Author

Anusha Sairavi

Oregon Health & Science UniversityORCID 0000-0003-3296-3402Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Hiroyuki NakaiiD· 2 shared Alexander A. NevueiD· 1 shared Claudio V. MelloiD· 1 shared Hirokazu HiraiiD· 1 shared Lena Li· 1 shared Michael P. HutchensiD· 1 shared Ranjan DasiD· 1 shared Samuel J. Huang· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Hiroyuki NakaiORCID

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2 papers

Recent·Most cited

Megalin-mediated deterministic pseudotransduction in proximal tubules fundamentally challenges current understanding of AAV kidney transduction

Anusha Sairavi, Ranjan Das, Lena Li, Tahnee Groat, Yasunori Matsuzaki, Hirokazu Hirai, Michael P. Hutchens, Hiroyuki Nakai

The paper shows that AAV-mediated gene delivery to proximal tubules is not direct but relies on megalin-mediated uptake of reporter proteins from other organs, challenging current understanding.

bioRxiv · Oct 28, 2026 · PreprintBioengineering

Genomic loss of GPR108 disrupts AAV transduction in birds

Alexander A. Nevue, Anusha Sairavi, Samuel J. Huang, Hiroyuki Nakai, Claudio V. Mello

The paper shows that GPR108 absence in birds explains lower AAV transduction efficacy and demonstrates that human GPR108 expression and capsid modifications enhance transduction in zebra finch cells.

bioRxiv · May 16, 2024 · PreprintGenomics