Megalin-mediated deterministic pseudotransduction in proximal tubules fundamentally challenges current understanding of AAV kidney transduction
Anusha Sairavi, Ranjan Das, Lena Li, Tahnee Groat, Yasunori Matsuzaki, Hirokazu Hirai, Michael P. Hutchens, Hiroyuki Nakai
The paper shows that AAV-mediated gene delivery to proximal tubules is not direct but relies on megalin-mediated uptake of reporter proteins from other organs, challenging current understanding.
bioRxiv · Oct 28, 2026 · PreprintBioengineering