Striatal Dopaminergic Dysfunction Constrains Motor Invigoration in Parkinson's Disease
Birgitte Liang Chen Thomsen, Vytautas Labanauskas, Nora Raaf, Sune Gram Thomsen, Mikkel C. Vinding, Lisbeth Marner, Annemette Løkkegaard, David Meder, Hartwig Roman Siebner
This study links nigrostriatal dopamine loss to reduced motor vigour in Parkinson's disease using functional MRI and dopamine transporter PET, showing impaired striatal recruitment and reward-related signaling.
bioRxiv · Sep 11, 2026 · PreprintNeuroscience