Per Svenningsson

The paper develops a workflow to reduce autofluorescence in fresh-frozen human brain tissue for multiplexed spatial proteomics and characterizes autofluorescence as a spatially structured feature.

This paper uses 6-base sequencing to analyze DNA modifications in cerebrospinal fluid cell-free DNA, providing insights into neurodegenerative biology for liquid biopsy applications.

tDCS fields from a multidimensional diffusion MRI conductivity model stayed within a few percent of DTI and isotropic predictions in 29 participants; whole-brain field instead tracked CSF fraction.

This study develops CRISPR-based mouse lines for locus-specific DNA methylation editing and shows locus-dependent transcriptional effects in vivo.

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

This study shows that gut-to-brain propagation of alpha-synuclein fibrils induces REM sleep behavior disorder and other non-motor and motor Parkinson's disease phenotypes.

This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

The paper identifies a constitutively active mutant of the dopamine D2 receptor using computational methods and experimental validation.

This study investigates the role of the CHCHD2-CHCHD10 protein complex in mitochondrial dysfunction and lipid homeostasis in mice, showing its importance in motor function and disease resistance.

The paper develops a multi-omics guided differentiation protocol to generate PD-vulnerable midbrain dopaminergic neurons, showing improved yield and functional recovery in mice.

Met-ID is an open-source software for annotating chemical modifications in MALDI-MSI data, combining MS1 and MS2 functionalities with a customizable database.

This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

This study shows that SARS-CoV-2 and HSV-1 induce amyloid aggregation of proteins in human CSF, leading to soluble protein depletion, suggesting a potential mechanism linking viral infections to neurodegenerative diseases.

This study identifies a GGC expansion in the ZFHX3 gene as the cause of SCA4, associated with dysautonomia and motor neuron signs.

This paper introduces a spatial multimodal analysis method that integrates histology, mass spectrometry imaging, and spatial transcriptomics to study mRNA and metabolite distributions in brain tissues.

The paper constructs a single nuclei RNA sequencing atlas of mouse midbrain dopamine neurons, revealing continuous molecular diversity and identifying gene expression patterns linked to vulnerability in a Parkinsonism lesion model.

This study analyzes resting-state MEG data to show that Parkinson's disease is associated with widespread changes in cortical aperiodic activity, specifically increased λ values across most brain regions.

This study improves human embryonic stem cell differentiation into midbrain dopaminergic neurons using specific factors and reveals developmental dynamics and high-quality cell types through single-cell RNA-sequencing.

This study shows that PRC2-mediated repression is essential for maintaining identity and function of dopaminergic and serotonergic neurons, with loss leading to behavioral deficits.

This study measures CSF Aβ42 and GFAP levels in HD patients and carriers, finding higher Aβ42 and GFAP in manifest HD, with GFAP correlating with disease stage.

This study examines cortical beta bursts in Parkinson's disease patients on and off medication, finding reduced burst rates correlate with symptom severity.

This study shows reduced beta rebound in Parkinson's disease patients during proprioceptive stimulation compared to healthy controls, suggesting impaired cortical processing of proprioceptive feedback independent of dopaminergic effects.