Axel Thielscher

Multicenter reliability of electric field simulations: Evidence from a traveling-subjects study

This study evaluates the reliability of electric field simulations across multiple scanners and scans, finding high inter-scanner and scan-rescan reliability.

Cortical E-fields of deep brain stimulation in Parkinson's disease patients exceed typical E-field magnitudes of transcranial electrical stimulation

This study quantifies whole-brain E-field distributions from STN-DBS in Parkinson's patients, finding cortical peak magnitudes exceeding typical transcranial stimulation values.

Histologically Informed Multiscale Modeling of the Neuronal Elements Activated by TMS

The paper uses histological data and computational models to identify myelinated axon bends as potential targets for TMS, showing they have physiologically realistic activation thresholds.

Optimizing and assessing multichannel TMS focality

This study develops a framework to optimize and assess multichannel TMS focality, showing mTMS systems can achieve performance comparable to single-channel TMS for deeper cortical targets.

Harmonizing the stimulation dose of focal tDCS across target sites

This paper develops a computational framework to standardize tDCS stimulation doses across brain regions while preserving individual variability, validated in an independent sample.

TI-Toolbox: An Open-Source Software for Temporal Interference Stimulation Research

TI-Toolbox provides an open-source platform for temporal interference stimulation research, integrating neuroimaging tools and workflows for preprocessing, modeling, and analysis.

A New Method for Optimal Placement of Tumor Treating Fields Electrodes

This paper introduces a computational method for optimizing TTFields electrode placement, showing improved electric field intensity and coverage compared to clinical standards and random placements.

Deep learning to overcome human error and bias in electrode position extraction in tDCS-fMRI studies

The paper develops a deep learning model to automate electrode detection in tDCS-fMRI studies, outperforming manual and semi-automated methods in precision and reducing human bias.

Not two sides of the same coin: Divergent effects of motor state on corticospinal and cortical responses to TMS of motor cortex

The paper compares how motor state affects corticospinal and cortical responses to TMS, finding they are modulated differently.

Rostro-caudal TMS mapping of immediate transcranial evoked potentials reveals a pericentral crescendo-decrescendo pattern

The paper maps rostro-caudal transcranial evoked potentials (iTEPs) using TMS-EEG and compares them to motor-evoked potentials (MEPs), finding similar but distinct spatial patterns.

Single pointwise samples of electric field on a neuron model cannot predict activation threshold by brain stimulation

The paper shows that single pointwise E-field samples cannot predict neural activation thresholds, as thresholds depend on spatial integration of the E-field along the neural cable.

Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional connectivity between motor areas

This study uses dual-site beta tACS over primary motor cortices during bimanual coordination to modulate functional connectivity, finding altered connectivity but no behavioral changes.

A Leadfield-Free Optimization Framework for Transcranially Applied Electric Currents

The paper introduces a leadfield-free optimization framework for determining optimal electrode montages in brain stimulation techniques, demonstrating its effectiveness across multiple applications.

Fast FEM-based Electric Field Calculations for Transcranial Magnetic Stimulation

The paper optimizes a finite-element method for faster electric field calculations in transcranial magnetic stimulation, achieving higher update rates with reduced computational resources.

Personalized electric field simulations of deformable large TMS coils based on automatic position and shape optimization

This paper introduces a method for optimizing the position and shape of deformable TMS coils based on individual head anatomy, improving electric field simulations and enabling systematic dose-response comparisons.

Head And Shoulders - The Impact Of An Extended Head Model On The Simulation And Optimization Of Transcranial Electric Stimulation

The paper introduces an extended head model for transcranial electric stimulation simulations, showing improved accuracy for extracephalic montages and better focality in cerebellar stimulation.

Directional Sensitivity of Cortical Neurons Towards TMS Induced Electric Fields

The paper develops computationally efficient average response models of cortical neurons to estimate TMS-induced stimulation thresholds based on electric field orientation.

Transcranial magnetic stimulation of primary motor cortex elicits a site-specific immediate transcranial evoked potential

The paper records immediate transcranial evoked potentials (i-TEPs) from TMS of the primary motor cortex and finds they are site-specific and modulated by stimulation parameters.

Behavioral entrainment to rhythmic auditory stimulation can be modulated by tACS depending on the electrical stimulation field properties

This study shows that tACS can modulate auditory entrainment based on electric field properties, but optimal lags vary across individuals and sessions.

Evaluating the Influence of Anatomical Accuracy and Electrode Positions on EEG Forward Solutions

This study evaluates how anatomical accuracy and electrode positions affect EEG forward solutions, finding that SimNIBS provides more accurate results than MNE-Python and FieldTrip.

Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

This study evaluates how anatomical details affect electric fields in transcranial stimulation simulations using a non-human primate model.

tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

This paper investigates how the electric field induced by tDCS in the motor cortex correlates with changes in GABA levels, finding that grey matter volume modulates this relationship.

Short periods of bipolar anodal TDCS induce no instantaneous dose-dependent increase in cerebral blood flow in the targeted human motor cortex

This study investigates whether short-duration anodal TDCS induces dose-dependent increases in cerebral blood flow in the motor cortex, finding no such effect.

Relationship between high-frequency activity in the cortical sensory and the motor hand areas, and their regional myelin content

This study examines the relationship between high-frequency oscillations in the sensory and motor hand areas and regional myelin content in the human sensorimotor cortex.

Efficient high-resolution TMS mapping of the human motor cortex by nonlinear regression

This paper introduces a method to map the human motor cortex with high resolution using nonlinear regression of electric fields and motor evoked potentials.

On the Reconstruction of Magnetic ResonanceCurrent Density Images of the Human Brain:Pitfalls and Perspectives

This paper analyzes the limitations of current MRCDI reconstruction methods and proposes a statistical testing framework to improve accuracy in human brain current density imaging.

Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain

This paper improves the sensitivity and resolution of in-vivo magnetic resonance current density imaging (MRCDI) through methodological advancements and validates it using phantom and human brain experiments.

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

The paper identifies phenotypic variation in the precentral hand knob by mapping TMS-induced MEPs and linking it to structural and functional features.

A novel approach to localize cortical TMS effects

This paper introduces a method to precisely localize cortical areas stimulated by TMS using electric field modeling and MEP measurements, showing that tangential electric field magnitude and orientation are key factors.

The non-transcranial TMS-evoked potential is an inherent source of ambiguity in TMS-EEG studies

This study shows that TMS-evoked potentials (TEPs) include non-transcranial components from peripheral sensory and auditory processing, complicating interpretations of TMS-EEG studies.