Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolarity
William Conway, Daija Bobe, Vitaly L. Zimyanin, Gunar Fabig, Alex de Marco, Stefanie Redemann
The paper shows that Eg5 organizes antiparallel microtubule bundles in human metaphase spindles through density-driven steric interactions, independent of spindle bipolarity.
Nature Communications · Oct 29, 2026Peer-reviewedBiophysics