Osteocalcin binds to the GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Rupesh Agarwal, Rui-Song Ye, Micholas Dean Smith, Jeremy C. Smith, L. Darryl Quarles, Min Pi
This study shows that osteocalcin binds to a distinct allosteric site in GPRC6A's VFT domain, acting as a positive modulator and enhancing its signaling.
FASEB BioAdvances · Aug 14, 2024Peer-reviewedMolecular Biology