Author

Micholas Dean Smith

Oak Ridge National LaboratoryORCID 0000-0002-0777-7539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Jeremy C. SmithiD· 3 shared L. Darryl QuarlesiD· 2 shared Min PiiD· 2 shared Rupesh AgarwaliD· 2 shared Ana Cristina Chang-GonzaleziD· 1 shared Christopher W. MothiD· 1 shared Jackson C. Stempel· 1 shared Jason Andrew AmburniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioinformatics

Jeremy C. SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AltereGO: Prediction of Protein Function by Multimodal Fusion of Protein Language Models.

Jason Andrew Amburn, Jackson C. Stempel, Ana Cristina Chang-Gonzalez, Christopher W. Moth, Jens Meiler, Micholas Dean Smith, Jeremy C. Smith

AltereGO fuses protein language models and structure representations to predict molecular functions, achieving better performance than individual models and some existing methods.

bioRxiv · Oct 27, 2026 · PreprintBioinformatics

GPRC6A is a Potential Therapeutic Target for Metformin Regulation of Glucose Homeostasis in Mice

Min Pi, Rupesh Agarwal, Micholas Dean Smith, Jeremy C. Smith, L. Darryl Quarles

This study identifies GPRC6A as a potential target for metformin's glucose-lowering effects, showing metformin activates GPRC6A in vitro and in vivo.

bioRxiv · Aug 19, 2024 · PreprintPhysiology

Osteocalcin binds to the GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling

Rupesh Agarwal, Rui-Song Ye, Micholas Dean Smith, Jeremy C. Smith, L. Darryl Quarles, Min Pi

This study shows that osteocalcin binds to a distinct allosteric site in GPRC6A's VFT domain, acting as a positive modulator and enhancing its signaling.

FASEB BioAdvances · Aug 14, 2024Peer-reviewedMolecular Biology