Cell BiologybioRxivPreprint
Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes
Anh T. P. Ngo, Weronika Ortmann, Abigail E Skidmore…·Kandace L. Gollomp
This study identifies platelet factor 4 (PF4) as a mediator of endothelial antimicrobial activity, enhancing bacterial clearance and improving sepsis outcomes through clathrin-mediated endocytosis and reduced immunothrombosis.
DOI 10.1101/2025.09.02.673783