Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes
Anh T. P. Ngo, Weronika Ortmann, Abigail E Skidmore, Hyun‐Jun Kim, Jenna Oberg, Amrita Sarkar, Veronica Bochenek, Nate Levine, Lubica Rauova, Irina N. Chernysh, Zachary Martinez, Caroline J. Diorio, Mark Goulian, Victor Nizet, Mortimer Poncz, Kandace L. Gollomp
This study identifies platelet factor 4 (PF4) as a mediator of endothelial antimicrobial activity, enhancing bacterial clearance and improving sepsis outcomes through clathrin-mediated endocytosis and reduced immunothrombosis.
bioRxiv · Sep 2, 2025 · PreprintCell Biology