Metagenomic strain-resolved DNA modification patterns link extrachromosomal genetic elements to host strains
Shuai Wang, Allison K. Guitor, Luis E. Valentin-Alvarado, Rebecca E. Garner, Pengfei Zhang, Ming Yan, Ling-Dong Shi, Marie Charlotte Schoelmerich, Holly M. Steininger, Daniel M. Portik, Siyuan Zhang, Jeremy E. Wilkinson, Susan V. Lynch, Michael J. Morowitz, Matthias Hess, , Rohan Sachdeva
The paper introduces MODIFI, a tool for detecting DNA modifications in metagenomes, and identifies ECE-host linkages in environmental and human samples.
bioRxiv · Mar 28, 2026 · PreprintMicrobiology