Extracellular Vesicle-Mediated Delivery of HIF1a Reprograms Macrophages for resolutive response in Sepsis
Yeji Lee, Jiyoung Goo, Seongeon Cho, Seong A Kim, Gi‐Hoon Nam, Iljin Kim, Jong-Wan Park, Cherlhyun Jeong, In-San Kim
This study delivers HIF1 via extracellular vesicles to reprogram hepatic macrophages, promoting pro-efferocytic and pro-survival macrophage subsets to enhance sepsis resolution.
bioRxiv · Aug 29, 2024 · PreprintBioengineering