Author

Christal D. Sohl

Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, USAORCID 0000-0002-8048-0205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Grace Chao· 2 shared Mikella RobinsoniD· 2 shared Uduak Z. GeorgeiD· 2 shared An D. Hoang· 1 shared Angelica M. RiestraiD· 1 shared Ashley V Schwartz· 1 shared Ashley V. SchwartziD· 1 shared Bryn Baxter· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Grace Chao

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mutant Isocitrate Dehydrogenase 1 Alters Extracellular Vesicle Secretion and Cargo Composition in Cellular Models

Grace Chao, Ashley V Schwartz, Rachel Hobbs, Mikella Robinson, Bryn Baxter, Angelica M. Riestra, Sevin Turcan, Uduak Z. George, Ingrid R. Niesman, Christal D. Sohl

This study shows mutant IDH1 increases sEV secretion and alters their cargo composition in glioma and chondrosarcoma cells, with D2HG packaged into sEVs and cell-type-specific cargo remodeling.

bioRxiv · Nov 6, 2026 · PreprintCancer Biology

Catalytically distinct IDH1 mutants tune phenotype severity in tumor models

Mowaffaq Adam Ahmed Adam, Mikella Robinson, Ashley V. Schwartz, Grace A. Wells, An D. Hoang, Elene Albekioni, Cecilia Gallo, Grace Chao, Joi L. Weeks, Giovanni Quichocho, Uduak Z. George, Carrie Danielle House, Şevin Turcan, Christal Dyane Sohl

This study shows that IDH1 R132Q mutants produce more D2HG than R132H mutants, leading to more aggressive tumors through distinct epigenetic and transcriptomic changes.

bioRxiv · Apr 22, 2024 · PreprintGenomics