Joseph Jacob

This study maps human lung fibrosis in 3D, showing how structural changes in tissue microarchitecture drive maladaptive repair states and disease progression.

This study maps venous remodelling in IPF using multiscale imaging and molecular data, showing venous enlargement correlates with disease severity and poor survival.

This paper maps the connectivity of the adult human heart at the micron scale using hierarchical phase-contrast tomography, revealing structural relationships between myocardial, vascular, and neural systems.

This study identifies a monocyte-macrophage-fibroblast axis in post-COVID-19 lung fibrosis using multi-omic profiling and shows its potential as a therapeutic target.

This paper presents the first single-nucleus RNA sequencing atlas of pleuroparenchymal fibroelastosis, identifying novel cell states and their spatial organization in lung fibrosis.

This study uses high-resolution imaging to reveal detailed anatomical structures of the clitoris, including the trajectory and branching of the dorsal nerve.

The Human Organ Atlas provides open access to multiscale 3D imaging of human organs, along with tools and resources for analysis and research.

This paper demonstrates the application of Hierarchical Phase-Contrast Tomography (HiP-CT) in three biomedical case studies, revealing detailed organ structures at multiple scales.

This paper introduces a highly-automated pipeline for generating simulation-ready meshes of tubular structures, enabling CFD simulations across various biomedical and industrial applications.

This study evaluates computer-derived CT variables (CALIPER vessel-related structures) as predictors of outcome in IPF, finding they outperform FVC decline in predicting prognosis and increasing trial power when used as co-endpoints.