Rachel Clare Chambers

This study identifies a monocyte-macrophage-fibroblast axis in post-COVID-19 lung fibrosis using multi-omic profiling and shows its potential as a therapeutic target.

This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.

This study shows that an AKAP13 genetic variant promotes fibrosis by altering epithelial signaling, and inhibiting AKAP13's RhoGEF activity reduces fibrotic markers in IPF models.

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

This study shows that pyruvate metabolism affects fibroblast response to GLS1 inhibition during fibrosis, suggesting combined targeting of pyruvate metabolism and glutaminolysis as a therapeutic strategy.

This study investigates how glucocorticoids modulate RNA binding proteins ZFP36L1 and ZFP36L2, showing their role in transcriptional and post-transcriptional gene regulation through subcellular RNA binding and localization changes.

The paper uses Frac-seq to analyze microRNA effects on gene expression in asthma, identifying six key microRNAs that regulate ~90% of their targets and contribute to disease mechanisms.