Cancer BiologyNature GeneticsPeer-reviewed
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer
Elissa W.P. Wong, Merve Şahin, Rui Yang…·Ping Chi
The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.
10 citations