TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer
Elissa W.P. Wong, Merve Şahin, Rui Yang, UkJin Lee, Dan Li, Yingqian Ada Zhan, Rohan Misra, Fanny V. Tomas, Nawaf Alomran, Alexander Polyzos, Cindy J. Lee, Tuan Trieu, Alexander Martinez‐Fundichely, Thomas Wiesner, Andrew Rosowicz, , Ping Chi
The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.
Nature Genetics · Jun 30, 2025Peer-reviewedCancer Biology