Enhancer status in the primitive endoderm supports unrestricted lineage plasticity in regulative development
Madeleine Linneberg-Agerholm, Annika Charlotte Sell, Alba Redó Riveiro, Martin Proks, Teresa E. Knudsen, Marta Perera, Joshua M. Brickman
The paper shows that primitive endoderm cells can regenerate a complete blastocyst and develop to term, indicating their lineage plasticity and potential for multi-lineage differentiation.
bioRxiv · May 20, 2023 · PreprintDevelopmental Biology