Marta Perera

The paper shows that ERK signalling outcomes vary between cell types due to transcriptional repression and chromatin accessibility changes, with immediate early responses shared but refined by signal duration and gene regulatory networks.

The paper identifies ESCs co-expressing GATA6 and SOX2, showing their cooperative DNA binding in enhancers and role in lineage priming for embryonic and extra-embryonic differentiation.

The paper shows that primitive endoderm cells can regenerate a complete blastocyst and develop to term, indicating their lineage plasticity and potential for multi-lineage differentiation.

The paper investigates how cell cycle regulation influences transcriptional heterogeneity and lineage priming in embryonic stem cells differentiating into primitive endoderm.