Author

Nicholas J Friesenhahn

California Institute of TechnologyORCID 0000-0002-8129-0171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Aiden J. Aceves· 1 shared Jingzhou WangiD· 1 shared Stephen L. MayoiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBioengineering

Aiden J. Aceves

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1 paper

Recent·Most cited

BioengineeringProtein Engineering Design and SelectionPeer-reviewedJan 1, 2025

CDRxAbs: Antibody Small-Molecule Conjugates with Computationally Designed Target-Binding Synergy

Jingzhou Wang, Aiden J. Aceves, Nicholas J Friesenhahn, Stephen L. Mayo

This paper introduces CDRxAbs, a new class of antibody-small-molecule conjugates designed to enhance target binding affinity and specificity through computational protein design.

DOI 10.1093/protein/gzaf004

protein structuredeep learning

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