Uromodulin promotes immune zonation and inhibits alternative inflammasome-mediated activation of immune-to-collecting duct inflammatory signaling in early acute kidney injury
Angela R. Sabo, Azuma Nanamatsu, Dillen Wischmeier, Connor J. Gulbronson, Shehnaz Khan, Radmila Micanovic, Seth Winfree, Tarek M. El‐Achkar, Kaice A. LaFavers
This study investigates how Uromodulin affects immune zonation and inflammasome activity in kidney injury, showing it reduces inflammation and immune cell interactions in specific kidney regions.
bioRxiv · Mar 1, 2026 · PreprintPhysiology