Angela R. Sabo

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

DigitAb: Domain-Adaptive Cell Type Prediction Method from Light Microscopy Images

DigitAb predicts cell types from H&E-stained slides using deep learning, achieving high accuracy without specialized assays or immunostains.

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

Uromodulin promotes immune zonation and inhibits alternative inflammasome-mediated activation of immune-to-collecting duct inflammatory signaling in early acute kidney injury

This study investigates how Uromodulin affects immune zonation and inflammasome activity in kidney injury, showing it reduces inflammation and immune cell interactions in specific kidney regions.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules

The chromatin landscape of healthy and injured cell types in the human kidney

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury and matrix remodeling in patients with stone disease

This study maps the spatial transcriptomic landscape of the human kidney papilla in stone disease, identifying immune injury and matrix remodeling as key features.

Integration of spatial transcriptomic and single cell sequencing identifies expression patterns underlying immune and epithelial cell cross-talk in acute kidney injury

The paper integrates spatial transcriptomics and single cell sequencing to identify immune and epithelial cell cross-talk patterns in acute kidney injury models.