In Silico Post-screening of Anti-polymerization Agents to Treat Sickle Cell Disease
Qian Ying, Nazanin Ahmadi Daryakenari, K. Melissa Hallow, Lu Lu, Pierre A. Buffet, Ming Dao, Li He, George Em Karniadakis
This paper develops a computational platform to evaluate anti-sickling agents by integrating PK/PD models with RBC sickling kinetics, demonstrating its utility in predicting therapeutic efficacy and noncompliance outcomes for existing and potential drugs.
bioRxiv · Oct 25, 2025 · PreprintBioengineering