Pierre A. Buffet

This study compares parasite biomass in spleen-intact and splenectomized patients with acute P. vivax malaria, finding that 89% of total-body parasite biomass is splenic.

This paper develops a computational platform to evaluate anti-sickling agents by integrating PK/PD models with RBC sickling kinetics, demonstrating its utility in predicting therapeutic efficacy and noncompliance outcomes for existing and potential drugs.

This study uses DPD simulations to analyze how altered RBC properties in Gaucher Disease affect blood viscosity and bone health through three shear rate domains.

This study shows that Plasmodium falciparum undergoes a rapid metamorphosis after invading erythrocytes, mediated by PV6, which aids parasite survival by altering erythrocyte surface area.

This study identifies molecular and cellular changes in storage-induced senescent erythrocytes (SMEs) that lead to their clearance, showing altered metabolism, proteostasis, and membrane properties.

This study uses computational models to show that deformable interendothelial slits in the spleen better predict RBC filtration compared to rigid models, improving understanding of splenic hemodynamics and filtration mechanisms.