Author

Katie L. Saxby

University of LeicesterORCID 0000-0002-8183-7659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

Christopher P. NelsoniD· 2 shared Matthew J. BowniD· 2 shared Adam E. LockeiD· 1 shared Alex Hørby ChristenseniD· 1 shared Alicia C. Deng· 1 shared Anders WanhaineniD· 1 shared Aris BarasiD· 1 shared Ashok Inderraj HandaiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Christopher P. NelsonORCID

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2 papers

Recent·Most cited

Could Metformin use reduce abdominal aortic aneurysm risk? A Mendelian randomisation study using known Metformin targets

Katie L. Saxby, Frank Dudbridge, Nilesh J. Samani, Matthew J. Bown, Christopher P. Nelson

This study uses Mendelian randomisation to investigate a causal link between Metformin use and reduced abdominal aortic aneurysm risk, finding a statistically significant association.

medRxiv · Oct 13, 2023 · PreprintGenetic & Genomic Medicine

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Tanmoy Roychowdhury, Derek M. Klarin, Michael G. Levin, Joshua Michael Spin, Yae Hyun Rhee, Alicia C. Deng, Colwyn Ansel Headley, Ida L. Surakka, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Y. Shen, Whitney Hornsby, Ina Holst Laursen, Shefali S. Verma, , Scott M. Damrauer

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

medRxiv · May 27, 2022 · PreprintGenetic & Genomic Medicine