Author

Jiyuan An

QIMR Berghofer Medical Research InstituteORCID 0000-0002-8183-8248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:GWAS / association mapping· 1 Assay:imaging· 1

Frequent Co-Authors

Stuart MacGregoriD· 3 shared Eske M. DerksiD· 2 shared Jackson G. ThorpiD· 2 shared Jue‐Sheng OngiD· 2 shared Adrián I. CamposiD· 1 shared Alex William HewittiD· 1 shared Andrew David GrotzingeriD· 1 shared Andries T. MareesiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

Stuart MacGregorORCID

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3 papers

Recent·Most cited

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

Jackson G. Thorp, Adrián I. Campos, Andrew David Grotzinger, Zachary F. Gerring, Jiyuan An, Jue‐Sheng Ong, Wei Wang, Suyash Shringarpure, Enda M. Byrne, Stuart MacGregor, Nicholas G. Martin, Sarah Elizabeth Medland, Christel Maria Middeldorp, Eske M. Derks

The paper identifies novel genetic risk loci for depression and anxiety using factor analysis and genomic SEM, revealing shared and trait-specific genetic influences.

Nature Human Behaviour · Apr 15, 2021Peer-reviewedGenetic & Genomic Medicine

Automated AI labelling of optic nerve head enables new insights into cross-ancestry glaucoma risk and genetic discovery in over 280,000 images from the UK Biobank and Canadian Longitudinal Study on Aging

Xikun Han, Kaiah Steven, Ayub Qassim, Henry N. Marshall, Cameron Bean, Michael Tremeer, Jiyuan An, Owen M. Siggs, Puya Gharahkhani, Jamie E. Craig, Alex William Hewitt, Maciej Trzaskowski, Stuart MacGregor

The paper uses AI to label optic nerve head images, enabling cross-ancestry genetic studies and identifying over 200 new loci associated with glaucoma risk.

bioRxiv · Nov 3, 2020 · PreprintGenetics

Investigating Genetic Heterogeneity in Major Depression Through Item-level Genetic Analyses of the PHQ-9

Jackson G. Thorp, Andries T. Marees, Jue‐Sheng Ong, Jiyuan An, Stuart MacGregor, Eske M. Derks

This study performs item-level genetic analyses of the PHQ-9 to explore genetic heterogeneity in major depression, identifying novel loci and revealing distinct genetic correlations across symptoms.

Psychological Medicine · Sep 18, 2019Peer-reviewedGenetics