This study identifies shared genetic factors between brain iron deposition and Alzheimer's disease, revealing a polygenic basis and potential neuroimmune mechanisms.

medRxiv · Sep 9, 2026 · PreprintGenetic & Genomic Medicine

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease Comorbidities

Damian J. Woodward, William R. Reay, Briar Wormington, Santiago Díaz‐Torres, Jue‐Sheng Ong, Zachary F. Gerring, Jackson G. Thorp, Eske M. Derks

This study identifies genetic pleiotropy between major depressive disorder and four physical disease clusters, finding strong associations with gastrointestinal diseases and uncovering novel biological pathways.

Nature Genetics · Aug 26, 2026Peer-reviewedGenetic & Genomic Medicine

Disparities and trends in global representation of human genetics conferences: a 26-year longitudinal study of ASHG and ESHG

Hao Zheng, Ying Wang, Yosuke Tanigawa, Jue‐Sheng Ong, Stuart MacGregor, Liming Liang, M Kellis, Xikun Han

This study analyzes 26 years of abstracts from two major human genetics conferences to identify geographic disparities in researcher representation and oral presentation success.

medRxiv · Aug 12, 2025 · PreprintGenetic & Genomic Medicine

Discovery of genomic loci associated with sleep apnoea risk through multi-trait GWAS analysis with snoring

Adrián I. Campos, Nathan Ingold, Yunru Huang, Brittany L. Mitchell, Pik Fang Kho, Xikun Han, Luis M. García‐Marín, Jue‐Sheng Ong, Michelle Agee, Stella Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, , Miguel E. Rentería

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

SLEEP · Dec 16, 2022Peer-reviewedGenetic & Genomic Medicine

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank Optical Coherence Tomography images

Hannah Currant, Pirro G. Hysi, Tomas W. Fitzgerald, Puya Gharahkhani, Pieter W. M. Bonnemaijer, Anne Senabouth, Alex William Hewitt, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie E. Craig, Peng Tee Khaw, Caroline C. W. Klaver, Michiaki Kubo, , Anthony P. Khawaja

The paper identifies 46 genetic loci associated with retinal thickness using OCT images from UK Biobank, finding new links to foveal hypoplasia and visual acuity.

PLoS Genetics · May 12, 2021Peer-reviewedGenetic & Genomic Medicine

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

Jackson G. Thorp, Adrián I. Campos, Andrew David Grotzinger, Zachary F. Gerring, Jiyuan An, Jue‐Sheng Ong, Wei Wang, Suyash Shringarpure, Enda M. Byrne, Stuart MacGregor, Nicholas G. Martin, Sarah Elizabeth Medland, Christel Maria Middeldorp, Eske M. Derks

The paper identifies novel genetic risk loci for depression and anxiety using factor analysis and genomic SEM, revealing shared and trait-specific genetic influences.

Nature Human Behaviour · Apr 15, 2021Peer-reviewedGenetic & Genomic Medicine

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

Puya Gharahkhani, Eric Jorgenson, Pirro G. Hysi, Anthony P. Khawaja, Sarah A. Pendergrass, Xikun Han, Jue‐Sheng Ong, Alex William Hewitt, Ayellet V. Segrè, Robert P. Igo, Hélène Choquet, Ayub Qassim, Navya Shilpa Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, , Janey L. Wiggs

bioRxiv · Jan 30, 2020 · PreprintGenetics

Investigating Genetic Heterogeneity in Major Depression Through Item-level Genetic Analyses of the PHQ-9

Jackson G. Thorp, Andries T. Marees, Jue‐Sheng Ong, Jiyuan An, Stuart MacGregor, Eske M. Derks

This study performs item-level genetic analyses of the PHQ-9 to explore genetic heterogeneity in major depression, identifying novel loci and revealing distinct genetic correlations across symptoms.

Psychological Medicine · Sep 18, 2019Peer-reviewedGenetics

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

Renato A Polimanti, Roseann Elizabeth Peterson, Jue‐Sheng Ong, Stuart MacGregor, Alexis C. Edwards, Toni‐Kim Clarke, Josef Frank, Zachary F. Gerring, Nathan A. Gillespie, Penelope A. Lind, HERMINE H. M. MAES, Nicholas G. Martin, Hamdi Mbarek, Sarah Elizabeth Medland, Fabian Streit, , Eske M. Derks

This study uses Mendelian randomization to find a causal link between major depression and alcohol dependence using large genetic datasets.

Psychological Medicine · Apr 1, 2019Peer-reviewedGenetics

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

Joëlle A. Pasman, Karin J. H. Verweij, Zachary F. Gerring, Sven Stringer, Sandra Sanchez‐Roige, Jorien L. Treur, Abdel Abdellaoui, Michel Guillaume Nivard, Bart M. L. Baselmans, Jue‐Sheng Ong, Hill Fung Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, , Jacqueline M. Vink

This study identifies 4 new risk loci for cannabis use through GWAS, finds genetic overlap with mental health, and shows a causal link between schizophrenia and cannabis use.

bioRxiv · Jan 8, 2018 · PreprintGenetics