Christel Maria Middeldorp

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

This paper conducts a genome-wide association meta-analysis of age at onset of walking, identifying 11 loci and showing genetic correlations with ADHD, BMI, intelligence, and brain structure.

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

This study integrates GWAS and exome data with single-cell gene expression to show common and ultra-rare schizophrenia variants are enriched in brain-expressed, selection-sensitive genes.

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

The paper identifies novel genetic risk loci for depression and anxiety using factor analysis and genomic SEM, revealing shared and trait-specific genetic influences.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

This paper uses GWAS data from MDD to identify potential drug targets and repurposing opportunities by analyzing drug-target networks and gene expression effects.

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.