Niamh Duggan

Adaptation of Burkholderia cenocepacia to low oxygen drives changes consistent with adaptation to chronic infection

This study shows that long-term hypoxia exposure of Burkholderia cenocepacia leads to proteomic changes and increased virulence traits consistent with adaptation to chronic infection in cystic fibrosis.

From colonisation to chronicity: adaptation of Mycobacterium abscessus in the cystic fibrosis lung environment

This study examines how Mycobacterium abscessus adapts during chronic infection in the CF lung, showing increased host cell attachment and intracellular survival in late isolates.

Long-term adaptation to hypoxia provides insight into mechanisms facilitating the switch of Pseudomonas aeruginosa to chronic lung infections

This study shows that long-term hypoxia exposure leads to stable phenotypic and proteomic changes in Pseudomonas aeruginosa, similar to those observed in chronic CF lung infections.