Siobhán McClean

OrthoGather provides a user-friendly platform for comparative proteomic analysis and Gene Ontology enrichment across species, enabling functional interpretation of protein sets without computational expertise.

This study shows that long-term hypoxia exposure of Burkholderia cenocepacia leads to proteomic changes and increased virulence traits consistent with adaptation to chronic infection in cystic fibrosis.

This study examines how Mycobacterium abscessus adapts during chronic infection in the CF lung, showing increased host cell attachment and intracellular survival in late isolates.

This study identifies cross-reactive vaccine antigens in Gram-positive ESKAPE pathogens using subtractive proteome analysis and opsonic activity testing.

The paper identifies proteins that show increased abundance in late-stage Pseudomonas aeruginosa isolates from CF patients, suggesting positive selection and adaptation to chronic infection.

This study shows that long-term hypoxia exposure leads to stable phenotypic and proteomic changes in Pseudomonas aeruginosa, similar to those observed in chronic CF lung infections.