Author

John Franklin

University of SheffieldORCID 0000-0002-8229-5337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Calum HarveyiD· 2 shared Cleide Dos Santos SouzaiD· 2 shared Jack N.G. MarshalliD· 2 shared Johnathan Cooper‐KnockiD· 2 shared Laura FerraiuoloiD· 2 shared Michael P. SnyderiD· 2 shared Pamela J. ShawiD· 2 shared Sai ZhangiD· 2 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Calum HarveyORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

Tobias Moll, Valerie Odon, Calum Harvey, Mark O. Collins, Andrew A. Peden, John Franklin, Emily J Graves, Jack N.G. Marshall, Cleide Dos Santos Souza, Sai Zhang, Lydia M. Castelli, Guillaume M. Hautbergue, Mimoun Azzouz, David Ezra Gordon, Nevan J. Krogan, , Johnathan Cooper‐Knock

The paper identifies reduced EXOSC2 expression as protective against SARS-CoV-2 infection and clinical COVID-19 by inhibiting viral replication and upregulating antiviral genes.

Life Science Alliance · Oct 14, 2022Peer-reviewedGenetics

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

Sai Zhang, Johnathan Cooper‐Knock, Annika K K Weimer, Minyi Shi, Tobias Moll, Jack N.G. Marshall, Calum Harvey, Helia Ghahremani Nezhad, John Franklin, Cleide Dos Santos Souza, Ke Ning, Cheng Wang, Jingjing Li, Allison Ann Dilliott, Sali M.K. Farhan, , Michael P. Snyder

This study identifies 690 candidate ALS genes using a hierarchical Bayesian model, highlighting genetic convergence on the distal axon and functional significance in motor neurons.

Neuron · Jan 18, 2022Peer-reviewedGenomics