Mark O. Collins

Repurposing clofarabine against enteric pathogens via metabolic starvation

This study identifies clofarabine as an inhibitor of EPEC pathogenesis by targeting bacterial and host translation, revealing a bacterial mechanism to counteract its effects.

Extracellular matrix properties and dynamics are important for butterfly scale nanostructure development

The paper investigates genes involved in extracellular matrix development in butterfly scales using RNA-seq and proteomics, identifying key genes affecting scale morphology and structure.

Isolation Strategy Shapes the Matrisome Landscape of Cancer-Associated Fibroblast Extracellular Vesicles

This study compares EV isolation methods and shows that compliance with MISEV2023 does not ensure equivalent EV composition, highlighting method-dependent differences in matrisome landscapes.

Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever

This study shows that typhoid toxin from Salmonella Typhi triggers DNA damage responses, leading to antimicrobial effects like lysozyme secretion that inhibit bacterial virulence.

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The paper identifies the CD9 interactome in epithelial cells during bacterial infection, showing species-specific interactions and demonstrating a CD9-derived peptide can block bacterial adherence.

An unbiased screening approach for identifying proteins with a mechanosensitive nuclear localization

The paper describes a screening method to identify proteins whose nuclear localization is sensitive to mechanical forces using engineered cell lines and LC-MS/MS.

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson's Disease

This study identifies secondary nucleation of α-Synuclein as the key mechanism driving mitochondrial dysfunction and Lewy body formation in Parkinson's Disease.

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

The paper identifies molecular determinants of HDAC1 complex assembly through mutations, showing that specific residues are critical for complex binding and gene regulation.

Glutathione Oxidation in Cerebrospinal Fluid as a Biomarker of Oxidative Stress in Amyotrophic Lateral Sclerosis

This study measures glutathione oxidation in cerebrospinal fluid of ALS patients and healthy controls, finding elevated levels and correlations with disease progression and protein oxidation.

Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.

Rapid degradation of Histone Deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription

This study rapidly degrades HDAC1 in ESCs to show its dual role in gene repression and active transcription by modulating histone acetylation at promoters and enhancers.

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy

The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

The paper identifies reduced EXOSC2 expression as protective against SARS-CoV-2 infection and clinical COVID-19 by inhibiting viral replication and upregulating antiviral genes.

DLG2 knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognition

This study identifies neurogenic transcriptional programs linked to neuropsychiatric disorders and cognition using DLG2 knockout models and transcriptomic data.

Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in mice

The paper develops methods to specifically visualize and isolate endogenous synaptic proteins in mice, revealing differences in PSD95 complex composition across cell types.

LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation.

This study identifies HDAC6 as a novel LRRK2 substrate and shows that LRRK2-mediated phosphorylation of HDAC6 enhances aggresome formation, linking LRRK2 dysfunction to Parkinson's disease pathology.

Regulation of somatosensory mechanotransduction by Annexin A6

This study identifies Annexin A6 as a modulator of somatosensory mechanotransduction by affecting mechanically-activated currents in sensory neurons.