Author

Dina Ruano

Leiden University Medical CenterORCID 0000-0002-8231-3398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexandra M. J. LangersiD· 1 shared Anja WagneriD· 1 shared Anne‐Marie Cleton-JanseniD· 1 shared Arjen R. MensenkampiD· 1 shared Carli M.J. TopsiD· 1 shared Debora M. MeijeriD· 1 shared Demi van EgmondiD· 1 shared Diantha TerlouwiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexandra M. J. LangersORCID

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2 papers

Recent·Most cited

Prevalence and consequences of APC mosaicism in patients with colorectal adenomas

Diantha Terlouw, Manon Suerink, Yentl Buitelaar, Monique Esther van Leerdam, Frederik Jan Hes, Demi van Egmond, Dina Ruano, Anja Wagner, Floris H. Groenendijk, Isabelle C. Meijssen, Eline Overwater, Sanne W. ten Broeke, Arjen R. Mensenkamp, Iris D Nagtegaal, Carli M.J. Tops, , Maartje Nielsen

The paper identifies APC mosaicism in patients with colorectal adenomas, finds higher prevalence in those meeting hereditary polyposis guidelines, and recommends targeted testing and surveillance.

medRxiv · Feb 18, 2025 · PreprintGenetic & Genomic Medicine

The variable genomic landscape during osteosarcoma progression: insights from a longitudinal WGS analysis

Debora M. Meijer, Dina Ruano, Inge H. Briaire‐de Bruijn, Pauline M. Wijers‐Koster, Michiel A. J. van de Sande, Hans A. J. Gelderblom, Anne‐Marie Cleton-Jansen, Noel F.C.C. de Miranda, Marieke L. Kuijjer, Judith V.M.G. Bovée

This study analyzes the genomic changes in osteosarcoma over time using WGS, revealing increasing genomic complexity and variable evolutionary patterns.

Genes Chromosomes and Cancer · Jul 1, 2024Peer-reviewedGenetic & Genomic Medicine