This study links immune infiltration in chordomas to increased transcriptional activity and distinct metabolic profiles, but causality remains unclear.

iScience · Apr 9, 2026Peer-reviewedCancer Biology

Identification and Characterization of Neoplastic Cells in Keratin-Positive Giant Cell-Rich Tumors

Maarten van der Linde, John S.A. Chrisinger, Elizabeth G. Demicco, Carina Anja Dehner, Gregory W. Charville, Inge H. Briaire‐de Bruijn, Sushama Varma, Chenchen Zhu, Magdalena Matusiak, Judith V.M.G. Bovée, Matt van de Rijn, David G.P. van IJzendoorn

This paper uses single-nuclei RNA sequencing and spatial transcriptomics to characterize KPGCT, showing neoplastic cells express HMGA2::NCOR2 fusions and activate the hippo pathway, driving CSF1 production and macrophage recruitment.

bioRxiv · Apr 7, 2026 · PreprintCancer Biology

Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma

Siddh van Oost, Debora M. Meijer, Zeynep Betül Erdem, Marieke E. Ijsselsteijn, Jessica P Roelands, Suk Wai Lam, Melissa Suraya Boejharat, Brendy E.W.M. van den Akker, Ruud van der Breggen, Inge H. Briaire‐de Bruijn, Lukas J.A.C. Hawinkels, Anouk A. Kruiswijk, Manon van der Ploeg, Pauline M. Wijers‐Koster, Rick L. Haas, , Judith V.M.G. Bovée

This study compares immunogenic features between undifferentiated soft tissue sarcoma and myxofibrosarcoma, finding differences in T cell and macrophage infiltration and their prognostic significance.

Cancer Immunology Immunotherapy · Jul 2, 2025Peer-reviewedCancer Biology

The variable genomic landscape during osteosarcoma progression: insights from a longitudinal WGS analysis

Debora M. Meijer, Dina Ruano, Inge H. Briaire‐de Bruijn, Pauline M. Wijers‐Koster, Michiel A. J. van de Sande, Hans A. J. Gelderblom, Anne‐Marie Cleton-Jansen, Noel F.C.C. de Miranda, Marieke L. Kuijjer, Judith V.M.G. Bovée

This study analyzes the genomic changes in osteosarcoma over time using WGS, revealing increasing genomic complexity and variable evolutionary patterns.

Genes Chromosomes and Cancer · Jul 1, 2024Peer-reviewedGenetic & Genomic Medicine