Alan D. Grossman

Positive control of the integrative and conjugative element Tn916 and its limited gene expression in transconjugants

This study identifies Sig7-8 as a two-subunit sigma factor in Tn916 that activates transcription but causes cell death, and shows that gene expression from Psig7 is limited in transconjugants.

Identification of insertion sites for the integrative and conjugative element Tn916 in the Bacillus subtilis chromosome

The paper identifies and maps Tn916 insertion sites in Bacillus subtilis chromosome, revealing a consensus motif and a hotspot region.

An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis

The paper identifies an antisense RNA, ArrA, that inhibits DnaA production in Bacillus subtilis and affects sporulation timing.

A phage-encoded counter-defense inhibits an NAD-degrading anti-phage defense system

The paper identifies a phage-encoded counter-defense gene that inhibits a bacterial NAD-degrading anti-phage defense system, enabling phage survival.

Activation and modulation of the host response to DNA damage by an integrative and conjugative element

The paper investigates how the integrative and conjugative element ICEBs1 modulates the host SOS response to DNA damage in Bacillus subtilis.

Transcription termination and antitermination are critical for the fitness and function of the integrative and conjugative element Tn916

This study identifies transcription termination and antitermination mechanisms in Tn916, showing they are critical for element function and host fitness.

Regulation of the SOS response and homologous recombination by an integrative and conjugative element

The paper shows that ICEBs1 proteins RamT and RamA inhibit the SOS response and homologous recombination in recipient bacteria by affecting SsbA binding and PcrA activity.