Sabarinadh Chilaka

This study shows H3K4me3 is a post-transcriptional histone mark, not a cause but a consequence of transcriptional activation, with delayed deposition relative to RNA synthesis.

The paper investigates replication timing stochasticity in single cells, finding that late-replicating loci exhibit similar stochasticity to early ones, suggesting variation in origin efficiency.

The paper identifies minimal cis-element modules that can shift replication timing and form early-replicating domains when combined.