Caroline Brossas

This study shows that transcription represses replication origin activity in late-replicating regions, leading to fragile site formation.

The paper identifies dimeric G-quadruplex motifs as key determinants of replication origins by inducing nucleosome-free regions and H2A.Z enrichment in vertebrates.

The paper investigates how transcription affects replication dynamics and genome stability in large genes, finding that moderate transcription increases instability while high transcription reduces it.

The paper identifies minimal cis-element modules that can shift replication timing and form early-replicating domains when combined.