Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study
Dario Pfyffer, Yiyu Wang, Merve Kaptan, Joel Fundaun, Troy C. Dildine, Valeria Oliva, Teresa Indriolo, Stefan T. Skare, Tim Sprenger, Philip Kenneth Lee, Minh Truong, Kenneth Arnold Weber II, Gary H. Glover, Christine Sze Wan Law, Sean Mackey
This study uses simultaneous spinal cord-brain fMRI to show how nociceptive stimuli and pain perception are encoded in corticospinal networks, with spinal cord activity primarily reflecting stimulus temperature.
bioRxiv · Oct 24, 2025 · PreprintNeuroscience