Author

Taimoor I. Sheikh

Centre for Addiction and Mental HealthORCID 0000-0002-8251-6574Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

John B. VincentiD· 3 shared A Heidari· 1 shared A Mikhailov· 1 shared Abdul NooriD· 1 shared Alexia Martínez de PaziD· 1 shared Alina Piekna· 1 shared Alysson Renato MuotriiD· 1 shared Asif MiriD· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersGenetics

John B. VincentORCID

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Author profile →

3 papers

Recent·Most cited

NeuroscienceTranslational PsychiatryPeer-reviewedOct 17, 2022

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations

Rebecca S.F. Mok, Wenbo Zhang, Taimoor I. Sheikh…·James Ellis

This study examines the effects of MECP2 mutations on neuronal and network phenotypes in human stem cell-derived excitatory neurons, showing a spectrum of morphological, electrophysiological, and circuitry changes based on mutation severity.

35 citations

humanelectronic health records

GeneticsHuman Molecular GeneticsPeer-reviewedJul 26, 2017

The role of N-terminal modification of MeCP2 in the pathophysiology of Rett syndrome

Taimoor I. Sheikh, Alexia Martínez de Paz, Shamim Akhtar…·John B. Vincent

This paper investigates N-terminal modifications of MeCP2 isoforms and their impact on protein degradation, showing that the p.Ala2Val mutation reduces protein stability and bioavailability in Rett syndrome.

28 citations

humanprotein sequence

GeneticsMolecular PsychiatryPeer-reviewedApr 11, 2017

Mapping Autosomal Recessive Intellectual Disability: Combined Microarray and Exome Sequencing Identifies 26 Novel Candidate Genes in 192 Consanguineous Families

Ricardo Harripaul, Nasim Vasli, A Mikhailov…·John B. Vincent

182 citationstop 1%

humanwhole-exome sequencing