Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
Parnian Arafi, Sujan Devkota, Emily M. Williams, Masato Maesako, Michael S. Wolfe
This study shows that FAD mutations in PSEN1 and APP cause stalled γ-secretase complexes, leading to synaptic degeneration, and that the F386S mutation specifically affects Aβ trimming without impairing endoproteolysis.
bioRxiv · Aug 30, 2024Biochemistry