Masato Maesako

This study develops a method to isolate and profile membrane lipids of vulnerable and resilient neurons to investigate their differential responses to oxidative stress.

The paper shows lipidated ApoE is closely located to Aβ aggregates in human Alzheimer's brains, suggesting a role in plaque formation.

This study records γ-secretase activity in living mouse brains using a NIR biosensor and microscopy, revealing cell non-autonomous regulation of the enzyme.

This study shows that FAD mutations in PSEN1 and APP cause stalled γ-secretase complexes, leading to synaptic degeneration, and that the F386S mutation specifically affects Aβ trimming without impairing endoproteolysis.

This study shows that Alzheimer's mutations stabilize harmful enzyme-substrate complexes in gamma-secretase, leading to synaptic loss rather than the released Aβ peptides being the primary cause.