Author

David M. Wood

University of CanterburyORCID 0000-0002-8275-3510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Renwick C. J. DobsoniD· 3 shared Borries DemeleriD· 2 shared Michael D. W. GriffiniD· 2 shared Rachel A. NorthiD· 2 shared Santosh PanjikariD· 2 shared Zachary D. Tillett· 2 shared Amy HenricksoniD· 1 shared Ashleigh S. JohnsiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMolecular Biology

Renwick C. J. DobsonORCID

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3 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedSep 22, 2026

Mechanism of NanR transcriptional activation of sialic acid metabolism in Streptococcus pneumoniae.

David M. Wood, Ashleigh S. Johns, Zachary D. Tillett…·Christopher R Horne

This study identifies how SpNanR activates sialic acid metabolism in S. pneumoniae by binding N-acetylmannosamine-6-phosphate, stabilizing its tetramer and enhancing transcription of the nan and siaA operons.

DOI 10.1093/nar/gkag953

bacteria (other)experimental assay

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NeurosciencebioRxivPreprintSep 18, 2025

The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily

Thomas W. Bird, Sepideh Valimehr, David M. Wood…·Davide Comoletti

This study determines the trimeric structures of FAM171A1 and FAM171A2 extracellular domains, revealing a novel structural superfamily and their oligomerization properties.

DOI 10.1101/2025.09.18.675241

humanprotein structure

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Molecular BiologyNature CommunicationsPeer-reviewedMar 31, 2021

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar…·Renwick C. J. Dobson

This study elucidates how NanR represses sialic acid metabolism in E. coli by showing its cooperative DNA binding and allosteric regulation by N-acetylneuraminate.

43 citations

E. coliexperimental assay

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