Author
The University of SydneyORCID 0000-0001-5011-1567Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
David M. Wood, Ashleigh S. Johns, Zachary D. Tillett…·Christopher R Horne
This study identifies how SpNanR activates sialic acid metabolism in S. pneumoniae by binding N-acetylmannosamine-6-phosphate, stabilizing its tetramer and enhancing transcription of the nan and siaA operons.
Alanah Grace Eisenhuth, Lachlan S. R. Adamson, Catherine Zhang…·Matthew Thomas Doyle
This study identifies TAM as a bacterial phospholipid transport system, revealing its structure and mechanism for lipid delivery to the outer membrane.
T.-R. J. King-Hudson, James S. Davies, Senwei Quan…·Renwick C. J. Dobson
This study solves the structure of the TRAP substrate-binding protein AaSiaP in different conformations, revealing how it binds N-acetylneuraminate and stabilizes a closed state.
James S. Davies, Michael J. Currie, Rachel A. North…·Renwick C. J. Dobson
The paper reports the cryo-EM structure of a TRAP transporter and elucidates its mechanism of sodium-driven substrate uptake.
Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar…·Renwick C. J. Dobson
This study elucidates how NanR represses sialic acid metabolism in E. coli by showing its cooperative DNA binding and allosteric regulation by N-acetylneuraminate.