Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response
Andréa Cottignies-Calamarte, Flora Marteau, Feifan He, Sandrine Belouzard, Jean Dubuisson, Daniela Tudor, Benoît Viollet, Morgane Bomsel
This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.
Journal of Virology · Jun 12, 2025Peer-reviewedImmunology